The mnemonic
Rest, Depolarise, Peak, Repolarise, Hyperpolarise
What each word stands for
- RestMembrane near K⁺ equilibrium, about −70 mV
- DepolariseNa⁺ channels open, Na⁺ enters
- PeakNa⁺ channels inactivate near +30 mV
- RepolariseK⁺ channels open, K⁺ leaves
- HyperpolariseK⁺ channels close slowly, brief undershoot
Why it matters clinically
Explains refractory periods and the action of sodium channel blockers.
Where it stops being reliable
It lists phases only; it does not explain channel kinetics in detail.
Teaching aid, still awaiting independent review. Confirm facts in a standard source.