Cardiovascular: losartan and uric acid: practice question

A Pharmacology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pharmacology · Cardiovascular: losartan and uric acid

Sample item

A hypertensive man with gout is considered for an ARB. Which ARB has a mild uricosuric effect?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Losartan

Losartan blocks the URAT1 transporter in the proximal tubule, lowering serum uric acid slightly, which can be useful in hypertensive patients with gout. Unlike ACE inhibitors, ARBs do not cause dry cough.

Option by option

  • A. Valsartan

    Valsartan lacks a uricosuric effect.

  • B. Telmisartan

    Telmisartan lacks this effect, though it has partial PPAR-gamma activity.

  • C. Olmesartan

    Olmesartan lacks a uricosuric effect.

  • D. Losartan (correct)

    Correct. Losartan is the ARB with a uricosuric action.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Pharmacology question

What is the answer to this Pharmacology question?

The best answer is D, Losartan. Losartan blocks the URAT1 transporter in the proximal tubule, lowering serum uric acid slightly, which can be useful in hypertensive patients with gout.

Why is "Valsartan" not the answer?

Valsartan lacks a uricosuric effect.

Why is "Telmisartan" not the answer?

Telmisartan lacks this effect, though it has partial PPAR-gamma activity.

Why is "Olmesartan" not the answer?

Olmesartan lacks a uricosuric effect.

What concept does this question test?

It tests Cardiovascular: losartan and uric acid in Pharmacology. Unlike ACE inhibitors, ARBs do not cause dry cough.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Cardiovascular: losartan and uric acid?

Learn drugs as classes, then the exception in each class that an examiner would pick. Then use the flashcards and the other Pharmacology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.