Critical care: tranexamic acid in trauma: practice question

A Anaesthesia question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Anaesthesia · Critical care: tranexamic acid in trauma

Sample item

In the CRASH-2 trial, tranexamic acid reduced mortality in bleeding trauma patients when given within which time?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. 3 hours of injury

Tranexamic acid, an antifibrinolytic, reduced death from bleeding when given within 3 hours of injury, and the benefit was greatest in the first hour. Later administration beyond 3 hours may increase risk. A loading dose of 1 g is followed by an infusion of 1 g over 8 hours.

Option by option

  • A. 24 hours of injury

    24 hours is too late for benefit.

  • B. 3 hours of injury (correct)

    Correct. Early administration within 3 hours is beneficial.

  • C. 12 hours of injury

    Beyond 3 hours the benefit is lost or reversed.

  • D. 72 hours of injury

    72 hours is too late for benefit.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Anaesthesia question

What is the answer to this Anaesthesia question?

The best answer is B, 3 hours of injury. Tranexamic acid, an antifibrinolytic, reduced death from bleeding when given within 3 hours of injury, and the benefit was greatest in the first hour.

Why is "24 hours of injury" not the answer?

24 hours is too late for benefit.

Why is "12 hours of injury" not the answer?

Beyond 3 hours the benefit is lost or reversed.

Why is "72 hours of injury" not the answer?

72 hours is too late for benefit.

What concept does this question test?

It tests Critical care: tranexamic acid in trauma in Anaesthesia. Later administration beyond 3 hours may increase risk. A loading dose of 1 g is followed by an infusion of 1 g over 8 hours.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Critical care: tranexamic acid in trauma?

Make a table of each agent, its key advantage and its main side effect. Then use the flashcards and the other Anaesthesia questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.