Nose and paranasal sinuses: eosinophilic granulomatosis with polyangiitis: practice question

A ENT question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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ENT · Nose and paranasal sinuses: eosinophilic granulomatosis with polyangiitis

Sample item

A 38-year-old man with adult-onset asthma and recurrent nasal polyps develops peripheral eosinophilia of 20 percent, mononeuritis multiplex and pulmonary infiltrates. Which antibody is typically positive?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. p-ANCA against myeloperoxidase

Eosinophilic granulomatosis with polyangiitis, formerly Churg-Strauss syndrome, features asthma, sinonasal polyposis, blood eosinophilia and vasculitis. MPO-ANCA (p-ANCA) is found in about 40 percent. c-ANCA is associated with granulomatosis with polyangiitis.

Option by option

  • A. p-ANCA against myeloperoxidase (correct)

    Correct. p-ANCA is typical.

  • B. c-ANCA against proteinase 3

    c-ANCA is characteristic of granulomatosis with polyangiitis.

  • C. Anti-centromere antibody

    Anti-centromere antibody suggests limited scleroderma.

  • D. Anti-dsDNA

    Anti-dsDNA suggests SLE.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this ENT question

What is the answer to this ENT question?

The best answer is A, p-ANCA against myeloperoxidase. Eosinophilic granulomatosis with polyangiitis, formerly Churg-Strauss syndrome, features asthma, sinonasal polyposis, blood eosinophilia and vasculitis.

Why is "c-ANCA against proteinase 3" not the answer?

c-ANCA is characteristic of granulomatosis with polyangiitis.

Why is "Anti-centromere antibody" not the answer?

Anti-centromere antibody suggests limited scleroderma.

Why is "Anti-dsDNA" not the answer?

Anti-dsDNA suggests SLE.

What concept does this question test?

It tests Nose and paranasal sinuses: eosinophilic granulomatosis with polyangiitis in ENT. MPO-ANCA (p-ANCA) is found in about 40 percent. c-ANCA is associated with granulomatosis with polyangiitis.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Nose and paranasal sinuses: eosinophilic granulomatosis with polyangiitis?

Learn tuning fork results and audiogram patterns by sketching them. Then use the flashcards and the other ENT questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.