Yellow fever vaccine: contraindications: practice question

A Microbiology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Microbiology · Yellow fever vaccine: contraindications

Sample item

Four people plan travel to a yellow fever endemic area. Who should not receive the live 17D vaccine?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. A 35-year-old with a history of anaphylaxis to egg protein

The 17D vaccine is a live attenuated strain grown in chick embryos, so severe egg allergy is a contraindication, as are significant immunosuppression, thymus disease and infancy. Healthy adults and those with controlled chronic disease may be vaccinated. International certificates are required by many countries for travellers from endemic areas.

Option by option

  • A. A 35-year-old with a history of anaphylaxis to egg protein (correct)

    Correct. Egg protein anaphylaxis contraindicates the egg-grown 17D vaccine.

  • B. A healthy 20-year-old student

    A healthy adult has no contraindication.

  • C. A 30-year-old using an inhaled corticosteroid

    Inhaled corticosteroids are not significantly immunosuppressive and do not preclude a live vaccine.

  • D. A 40-year-old with well-controlled type 2 diabetes

    Well-controlled diabetes is not an immunosuppressive contraindication.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Microbiology question

What is the answer to this Microbiology question?

The best answer is A, A 35-year-old with a history of anaphylaxis to egg protein. The 17D vaccine is a live attenuated strain grown in chick embryos, so severe egg allergy is a contraindication, as are significant immunosuppression, thymus disease and infancy.

Why is "A healthy 20-year-old student" not the answer?

A healthy adult has no contraindication.

Why is "A 30-year-old using an inhaled corticosteroid" not the answer?

Inhaled corticosteroids are not significantly immunosuppressive and do not preclude a live vaccine.

Why is "A 40-year-old with well-controlled type 2 diabetes" not the answer?

Well-controlled diabetes is not an immunosuppressive contraindication.

What concept does this question test?

It tests Yellow fever vaccine: contraindications in Microbiology. Healthy adults and those with controlled chronic disease may be vaccinated. International certificates are required by many countries for travellers from endemic areas.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Yellow fever vaccine: contraindications?

Make a one-line identity card for each organism: shape and stain, defining test, toxin, disease and drug. Then use the flashcards and the other Microbiology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.