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Physiology · Special senses: colour vision
Sample itemA man with red-green colour blindness marries a woman with normal vision whose family has no colour blindness. What are the expected outcomes in their children?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
D. All daughters are carriers and no sons are affected
Red and green cone pigment genes lie on the X chromosome, so the defects are X-linked recessive. The father gives his only X to all daughters, making them carriers, and his Y to sons, who receive the mother's normal X and are unaffected.
Option by option
A. Half the daughters are affected
Daughters have a normal maternal X and are heterozygous, not affected.
B. Half the sons are affected and all daughters are normal
Sons receive the mother's normal X, so they are not affected.
C. All sons are affected and all daughters are normal
Sons inherit the Y from the father and are not affected, and daughters are carriers.
D. All daughters are carriers and no sons are affected (correct)
Correct. Daughters receive the father's affected X and sons do not.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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