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Dermatology · Skin cancer
Sample itemWhich change in a pigmented lesion is concerning for melanoma?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
C. Evolving asymmetry, border, color, or size
Evolution in asymmetry, border irregularity, color variation, or diameter is concerning and merits clinical skin assessment for melanoma.
Option by option
A. A stable uniform freckle for years
Long-term stability is relatively reassuring.
B. A temporary pressure mark from clothing
Pressure marks are temporary mechanical changes.
C. Evolving asymmetry, border, color, or size (correct)
Correct: evolution in ABCD features is concerning.
D. A wart that clears spontaneously
A self-clearing wart is not the classic melanoma concern.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.