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Microbiology · Virology: influenza
Sample itemWhy does antigenic shift in influenza A have pandemic potential?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
B. Reassortment can create a novel haemagglutinin or neuraminidase subtype
Influenza A has a segmented genome, allowing reassortment between strains in a shared host. A novel surface-antigen combination may encounter little population immunity; gradual point mutation is antigenic drift.
Option by option
A. It is caused by bacterial superinfection
Bacterial superinfection is a complication, not the mechanism of shift.
B. Reassortment can create a novel haemagglutinin or neuraminidase subtype (correct)
Correct. Segment reassortment generates abrupt antigenic novelty.
C. Point mutations slowly alter one epitope
Slow point mutations describe antigenic drift.
D. The virus integrates into host DNA
Influenza is an RNA virus that does not require integration for replication.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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