Renal physiology: tubuloglomerular feedback: practice question

A Physiology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Physiology · Renal physiology: tubuloglomerular feedback

Sample item

High sodium chloride delivery to the macula densa causes which local response?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Afferent arteriolar constriction and reduced renin release

High distal NaCl signals excessive filtration. Macula densa signalling constricts the afferent arteriole and suppresses renin, reducing GFR toward normal.

Option by option

  • A. Afferent arteriolar constriction and reduced renin release (correct)

    Correct. This is the negative-feedback response to high distal salt delivery.

  • B. Efferent constriction through angiotensin II release

    Angiotensin II generation rises when renin is stimulated by low NaCl.

  • C. Afferent dilation and increased renin release

    Dilation and renin release occur when macula-densa NaCl is low.

  • D. Increased proximal sodium reabsorption directly

    The macula densa chiefly regulates arteriolar tone and renin, not direct proximal transport.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Physiology question

What is the answer to this Physiology question?

The best answer is A, Afferent arteriolar constriction and reduced renin release. High distal NaCl signals excessive filtration.

Why is "Efferent constriction through angiotensin II release" not the answer?

Angiotensin II generation rises when renin is stimulated by low NaCl.

Why is "Afferent dilation and increased renin release" not the answer?

Dilation and renin release occur when macula-densa NaCl is low.

Why is "Increased proximal sodium reabsorption directly" not the answer?

The macula densa chiefly regulates arteriolar tone and renin, not direct proximal transport.

What concept does this question test?

It tests Renal physiology: tubuloglomerular feedback in Physiology. Macula densa signalling constricts the afferent arteriole and suppresses renin, reducing GFR toward normal.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Renal physiology: tubuloglomerular feedback?

For each system, sketch the key graph (pressure–volume loop, oxygen dissociation curve, nephron handling) and explain it aloud. Then use the flashcards and the other Physiology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.