Neuromuscular blockade: rocuronium reversal: practice question

A Anaesthesia question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Anaesthesia · Neuromuscular blockade: rocuronium reversal

Sample item

Sugammadex reverses rocuronium primarily by what mechanism?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Encapsulating the neuromuscular blocker

Sugammadex is a cyclodextrin that binds steroidal neuromuscular blockers such as rocuronium and vecuronium in plasma, reducing free drug available at the endplate.

Option by option

  • A. Inhibiting acetylcholinesterase

    Neostigmine inhibits acetylcholinesterase.

  • B. Inhibiting calcium release

    Dantrolene inhibits skeletal-muscle calcium release.

  • C. Blocking muscarinic receptors

    Antimuscarinics offset neostigmine's muscarinic effects.

  • D. Encapsulating the neuromuscular blocker (correct)

    Correct. Encapsulation creates a concentration gradient away from the receptor.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Anaesthesia question

What is the answer to this Anaesthesia question?

The best answer is D, Encapsulating the neuromuscular blocker. Sugammadex is a cyclodextrin that binds steroidal neuromuscular blockers such as rocuronium and vecuronium in plasma, reducing free drug available at the endplate.

Why is "Inhibiting acetylcholinesterase" not the answer?

Neostigmine inhibits acetylcholinesterase.

Why is "Inhibiting calcium release" not the answer?

Dantrolene inhibits skeletal-muscle calcium release.

Why is "Blocking muscarinic receptors" not the answer?

Antimuscarinics offset neostigmine's muscarinic effects.

What concept does this question test?

It tests Neuromuscular blockade: rocuronium reversal in Anaesthesia. The correct option holds because: Correct. Encapsulation creates a concentration gradient away from the receptor.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Neuromuscular blockade: rocuronium reversal?

Make a table of each agent, its key advantage and its main side effect. Then use the flashcards and the other Anaesthesia questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.