Haematology: TTP: practice question

A General Medicine question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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General Medicine · Haematology: TTP

Sample item

Thrombocytopenia, microangiopathic haemolytic anaemia, neurologic symptoms and renal dysfunction suggest TTP. What therapy is urgent?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Plasma exchange

TTP results from severe ADAMTS13 deficiency and is treated urgently with plasma exchange plus immunosuppression. Platelets may worsen thrombosis unless bleeding is life threatening.

Option by option

  • A. Iron infusion

    Iron does not treat hemolysis from TTP.

  • B. Platelet transfusion alone

    Platelets do not correct the underlying microthrombosis.

  • C. Plasma exchange (correct)

    Correct. Plasma exchange replaces ADAMTS13 and removes autoantibody.

  • D. Vitamin K

    Vitamin K does not address platelet-rich microthrombi.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this General Medicine question

What is the answer to this General Medicine question?

The best answer is C, Plasma exchange. TTP results from severe ADAMTS13 deficiency and is treated urgently with plasma exchange plus immunosuppression.

Why is "Iron infusion" not the answer?

Iron does not treat hemolysis from TTP.

Why is "Platelet transfusion alone" not the answer?

Platelets do not correct the underlying microthrombosis.

Why is "Vitamin K" not the answer?

Vitamin K does not address platelet-rich microthrombi.

What concept does this question test?

It tests Haematology: TTP in General Medicine. Platelets may worsen thrombosis unless bleeding is life threatening.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Haematology: TTP?

For each disease know the classic presentation, the best test, and the first-line treatment. Then use the flashcards and the other General Medicine questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.