Diuretics: practice question

A Pharmacology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pharmacology · Diuretics

Sample item

Why can spironolactone cause breast tenderness?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Antiandrogenic effects

Spironolactone antagonizes mineralocorticoid receptors but also has antiandrogenic effects that may cause gynecomastia or breast tenderness.

Option by option

  • A. Thyroid hormone excess

    Thyroid excess is unrelated.

  • B. Acetylcholinesterase inhibition

    Cholinesterase inhibition causes cholinergic symptoms.

  • C. Direct dopamine blockade

    Dopamine blockade has other adverse effects.

  • D. Antiandrogenic effects (correct)

    Correct: antiandrogen action explains gynecomastia.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Pharmacology question

What is the answer to this Pharmacology question?

The best answer is D, Antiandrogenic effects. Spironolactone antagonizes mineralocorticoid receptors but also has antiandrogenic effects that may cause gynecomastia or breast tenderness.

Why is "Thyroid hormone excess" not the answer?

Thyroid excess is unrelated.

Why is "Acetylcholinesterase inhibition" not the answer?

Cholinesterase inhibition causes cholinergic symptoms.

Why is "Direct dopamine blockade" not the answer?

Dopamine blockade has other adverse effects.

What concept does this question test?

It tests Diuretics in Pharmacology. The correct option holds because: Correct: antiandrogen action explains gynecomastia.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Diuretics?

Learn drugs as classes, then the exception in each class that an examiner would pick. Then use the flashcards and the other Pharmacology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.