Try it
General Medicine · Neurology: dementia with Lewy bodies
Sample itemA 72-year-old man has fluctuating confusion, well-formed visual hallucinations of children, dream enactment behaviour during sleep and mild parkinsonism that appeared 6 months after the memory decline. He developed severe rigidity after a dose of haloperidol. What is the most likely diagnosis?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
D. Dementia with Lewy bodies
Dementia with Lewy bodies shows fluctuating cognition, recurrent visual hallucinations, REM sleep behaviour disorder and parkinsonism, with dementia appearing before or within a year of motor symptoms (otherwise Parkinson disease dementia). Patients are highly sensitive to antipsychotics, and cholinesterase inhibitors such as rivastigmine help.
Option by option
A. Behavioural variant frontotemporal dementia
Behavioural variant frontotemporal dementia presents with disinhibition and apathy rather than visual hallucinations.
B. Vascular dementia
Vascular dementia has a stepwise course with focal deficits and vascular risk factors.
C. Alzheimer disease
Alzheimer disease features prominent early amnesia and lacks early hallucinations and parkinsonism.
D. Dementia with Lewy bodies (correct)
Correct. The core clinical features and neuroleptic sensitivity define this disorder.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
More General Medicine questions
- EndocrinologyA 19-year-old with type 1 diabetes presents with vomiting, deep rapid breathing, fruity…
- ElectrolytesWhich is the earliest ECG change in hyperkalaemia?
- Infectious diseaseWhat is the drug of choice for Pneumocystis jirovecii pneumonia in a patient with advanc…
- NeurologyA chronic alcohol user is brought in confused, with nystagmus and an unsteady gait. What…