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General Surgery · Urology: haematuria work-up
Sample itemA 64-year-old man who smokes has had one episode of painless gross haematuria. Urine culture is sterile and ultrasound shows normal kidneys. What is the most appropriate next step?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
C. Flexible cystoscopy
Painless visible haematuria in a smoker is urothelial carcinoma until proven otherwise, and the bladder is the commonest source. Cystoscopy is the key investigation, and the upper tract is evaluated with CT urography. Normal ultrasound does not exclude bladder tumours. Repeated or persistent haematuria should never be dismissed as benign.
Option by option
A. Empirical antibiotics for 7 days
Antibiotics are inappropriate when urine culture is sterile.
B. Transrectal prostate biopsy
Prostate biopsy does not assess the bladder and is not indicated for haematuria alone.
C. Flexible cystoscopy (correct)
Direct visualisation of the bladder mucosa is needed to exclude urothelial cancer.
D. Observation and repeat urinalysis in 6 months
Waiting risks delaying the diagnosis of a possible malignancy.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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