Fractures and dislocations: demineralised bone matrix: practice question

A Orthopaedics question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Orthopaedics · Fractures and dislocations: demineralised bone matrix

Sample item

A surgeon packs a bone defect with demineralised bone matrix. Which property does this graft material provide?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Osteoconduction and osteoinduction, but no osteogenic cells

Demineralised bone matrix is processed allograft whose mineral has been removed to expose bone morphogenetic proteins and collagen. It is osteoinductive and osteoconductive, but contains no viable cells, so it is not osteogenic. Only autograft provides all three properties.

Option by option

  • A. Osteogenesis, osteoinduction and osteoconduction

    All three properties together describe fresh autograft with viable cells.

  • B. Osteogenesis only, from live osteoblasts

    DBM is acellular processed allograft and has no live osteoblasts.

  • C. Osteoconduction and osteoinduction, but no osteogenic cells (correct)

    Correct. DBM supplies a collagen scaffold and growth factors but no living cells.

  • D. Osteoconduction only, as a structural scaffold

    Purely osteoconductive materials include hydroxyapatite and tricalcium phosphate, which have no growth factors.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Orthopaedics question

What is the answer to this Orthopaedics question?

The best answer is C, Osteoconduction and osteoinduction, but no osteogenic cells. Demineralised bone matrix is processed allograft whose mineral has been removed to expose bone morphogenetic proteins and collagen.

Why is "Osteogenesis, osteoinduction and osteoconduction" not the answer?

All three properties together describe fresh autograft with viable cells.

Why is "Osteogenesis only, from live osteoblasts" not the answer?

DBM is acellular processed allograft and has no live osteoblasts.

Why is "Osteoconduction only, as a structural scaffold" not the answer?

Purely osteoconductive materials include hydroxyapatite and tricalcium phosphate, which have no growth factors.

What concept does this question test?

It tests Fractures and dislocations: demineralised bone matrix in Orthopaedics. It is osteoinductive and osteoconductive, but contains no viable cells, so it is not osteogenic. Only autograft provides all three properties.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Fractures and dislocations: demineralised bone matrix?

Pair each fracture with its classic complication and nerve injured. Then use the flashcards and the other Orthopaedics questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.