Chemotherapy: secukinumab cautions: practice question

A Pharmacology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pharmacology · Chemotherapy: secukinumab cautions

Sample item

A patient with moderate plaque psoriasis is to start secukinumab, an IL-17A antibody. Which pre-existing condition calls for particular caution because it may worsen on this drug?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Crohn disease

IL-17 inhibitors can exacerbate or unmask inflammatory bowel disease, and they also increase mucocutaneous candidiasis. Ankylosing spondylitis and psoriatic arthritis are approved indications for secukinumab, and gout is not worsened by it.

Option by option

  • A. Gout

    Gout is not made worse by IL-17 blockade.

  • B. Ankylosing spondylitis

    Ankylosing spondylitis is an approved indication for secukinumab.

  • C. Crohn disease (correct)

    Correct. IL-17 blockade can worsen Crohn disease.

  • D. Psoriatic arthritis

    Psoriatic arthritis is an approved indication for secukinumab.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Pharmacology question

What is the answer to this Pharmacology question?

The best answer is C, Crohn disease. IL-17 inhibitors can exacerbate or unmask inflammatory bowel disease, and they also increase mucocutaneous candidiasis.

Why is "Gout" not the answer?

Gout is not made worse by IL-17 blockade.

Why is "Ankylosing spondylitis" not the answer?

Ankylosing spondylitis is an approved indication for secukinumab.

Why is "Psoriatic arthritis" not the answer?

Psoriatic arthritis is an approved indication for secukinumab.

What concept does this question test?

It tests Chemotherapy: secukinumab cautions in Pharmacology. Ankylosing spondylitis and psoriatic arthritis are approved indications for secukinumab, and gout is not worsened by it.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Chemotherapy: secukinumab cautions?

Learn drugs as classes, then the exception in each class that an examiner would pick. Then use the flashcards and the other Pharmacology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.