Autonomic nervous system: teduglutide in short bowel syndrome: practice question

A Pharmacology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pharmacology · Autonomic nervous system: teduglutide in short bowel syndrome

Sample item

A woman with short bowel syndrome after extensive resection remains dependent on parenteral nutrition. Teduglutide is started. How does it reduce her dependence?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. As a GLP-2 analogue it promotes intestinal mucosal growth and absorption

Teduglutide is an analogue of glucagon-like peptide 2 that increases villus height and crypt depth and so enhances absorption. It can reduce the volume of parenteral support. Colonic polyps are a risk, so colonoscopy is done before and during treatment.

Option by option

  • A. As a somatostatin analogue it reduces intestinal secretions

    Somatostatin analogues lower secretions but do not promote mucosal growth.

  • B. As a GLP-1 analogue it slows gastric emptying

    GLP-1 analogues slow gastric emptying and lower glucose but are not the mechanism here.

  • C. As a GLP-2 analogue it promotes intestinal mucosal growth and absorption (correct)

    Correct. A GLP-2 analogue stimulates trophic growth of the intestinal mucosa.

  • D. As a proton pump inhibitor it reduces gastric acid output

    Acid suppression may reduce output but does not increase absorptive surface.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Pharmacology question

What is the answer to this Pharmacology question?

The best answer is C, As a GLP-2 analogue it promotes intestinal mucosal growth and absorption. Teduglutide is an analogue of glucagon-like peptide 2 that increases villus height and crypt depth and so enhances absorption.

Why is "As a somatostatin analogue it reduces intestinal secretions" not the answer?

Somatostatin analogues lower secretions but do not promote mucosal growth.

Why is "As a GLP-1 analogue it slows gastric emptying" not the answer?

GLP-1 analogues slow gastric emptying and lower glucose but are not the mechanism here.

Why is "As a proton pump inhibitor it reduces gastric acid output" not the answer?

Acid suppression may reduce output but does not increase absorptive surface.

What concept does this question test?

It tests Autonomic nervous system: teduglutide in short bowel syndrome in Pharmacology. It can reduce the volume of parenteral support. Colonic polyps are a risk, so colonoscopy is done before and during treatment.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Autonomic nervous system: teduglutide in short bowel syndrome?

Learn drugs as classes, then the exception in each class that an examiner would pick. Then use the flashcards and the other Pharmacology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.