Endocrinology: amylin: practice question

A Physiology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Physiology · Endocrinology: amylin

Sample item

A peptide co-secreted with insulin from pancreatic beta cells slows gastric emptying and suppresses post-meal glucagon release, and a synthetic analogue is used as an adjunct to insulin in diabetes. What is this peptide?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Amylin

Amylin is co-stored and co-secreted with insulin and reduces post-prandial glucose by slowing gastric emptying, suppressing glucagon and increasing satiety. It is deficient in type 1 diabetes. C-peptide is a connecting peptide released in equimolar amounts with insulin and has no such action.

Option by option

  • A. Amylin (correct)

    Correct. Amylin acts with insulin to blunt post-prandial glucose.

  • B. Glucose-dependent insulinotropic polypeptide

    GIP comes from K cells of the duodenum and stimulates insulin secretion.

  • C. C-peptide

    C-peptide is a marker of endogenous insulin secretion and has no glucose-lowering action here.

  • D. Proinsulin

    Proinsulin is a precursor with low biological activity.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Physiology question

What is the answer to this Physiology question?

The best answer is A, Amylin. Amylin is co-stored and co-secreted with insulin and reduces post-prandial glucose by slowing gastric emptying, suppressing glucagon and increasing satiety.

Why is "Glucose-dependent insulinotropic polypeptide" not the answer?

GIP comes from K cells of the duodenum and stimulates insulin secretion.

Why is "C-peptide" not the answer?

C-peptide is a marker of endogenous insulin secretion and has no glucose-lowering action here.

Why is "Proinsulin" not the answer?

Proinsulin is a precursor with low biological activity.

What concept does this question test?

It tests Endocrinology: amylin in Physiology. It is deficient in type 1 diabetes. C-peptide is a connecting peptide released in equimolar amounts with insulin and has no such action.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Endocrinology: amylin?

For each system, sketch the key graph (pressure–volume loop, oxygen dissociation curve, nephron handling) and explain it aloud. Then use the flashcards and the other Physiology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.