Larynx and airway: localised laryngeal amyloidosis: practice question

A ENT question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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ENT · Larynx and airway: localised laryngeal amyloidosis

Sample item

A middle-aged man with hoarseness has smooth, waxy yellow submucosal thickening of both ventricular folds. Biopsy shows amorphous pink deposits that stain with Congo red and show apple-green birefringence under polarised light. What is the most appropriate next step?

APerform a radical neck dissectionBLook for systemic amyloidosis, then manage endoscopicallyCStart definitive radiotherapy to the larynxDProceed to total laryngectomy

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Look for systemic amyloidosis, then manage endoscopically

Laryngeal amyloidosis is usually localised, but a systemic cause must be excluded. Management is conservative or repeated endoscopic or laser debulking to preserve the airway and voice, because the disease is benign.

Option by option

A. Perform a radical neck dissection
Neck dissection is for metastatic cancer, not amyloid.
B. Look for systemic amyloidosis, then manage endoscopically (correct)
Correct. Exclude systemic involvement, then debulk endoscopically if symptomatic.
C. Start definitive radiotherapy to the larynx
Radiotherapy has no established role and risks stenosis.
D. Proceed to total laryngectomy
Total laryngectomy is not justified for a benign deposition disease.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

Questions about this ENT question

What is the answer to this ENT question?

The best answer is B, Look for systemic amyloidosis, then manage endoscopically. Laryngeal amyloidosis is usually localised, but a systemic cause must be excluded.

Why is "Perform a radical neck dissection" not the answer?

Neck dissection is for metastatic cancer, not amyloid.

Why is "Start definitive radiotherapy to the larynx" not the answer?

Radiotherapy has no established role and risks stenosis.

Why is "Proceed to total laryngectomy" not the answer?

Total laryngectomy is not justified for a benign deposition disease.

What concept does this question test?

It tests Larynx and airway: localised laryngeal amyloidosis in ENT. Management is conservative or repeated endoscopic or laser debulking to preserve the airway and voice, because the disease is benign.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Larynx and airway: localised laryngeal amyloidosis?

Learn tuning fork results and audiogram patterns by sketching them. Then use the flashcards and the other ENT questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.