Head and neck tumours: adenoid cystic carcinoma genetics: practice question

A ENT question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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ENT · Head and neck tumours: adenoid cystic carcinoma genetics

Sample item

A salivary carcinoma with cribriform and tubular patterns shows a recurrent t(6;9) translocation producing a MYB-NFIB fusion. Which tumour is this?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Adenoid cystic carcinoma

The MYB-NFIB fusion from t(6;9) is characteristic of adenoid cystic carcinoma. Mucoepidermoid carcinoma carries the CRTC1-MAML2 fusion. Acinic cell carcinoma and Warthin tumour have different features.

Option by option

  • A. Acinic cell carcinoma

    Acinic cell carcinoma does not carry this fusion.

  • B. Adenoid cystic carcinoma (correct)

    Correct. MYB-NFIB is the signature fusion of adenoid cystic carcinoma.

  • C. Mucoepidermoid carcinoma

    Mucoepidermoid carcinoma carries CRTC1-MAML2.

  • D. Warthin tumour

    Warthin tumour is a benign oncocytic tumour without this fusion.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this ENT question

What is the answer to this ENT question?

The best answer is B, Adenoid cystic carcinoma. The MYB-NFIB fusion from t(6;9) is characteristic of adenoid cystic carcinoma.

Why is "Acinic cell carcinoma" not the answer?

Acinic cell carcinoma does not carry this fusion.

Why is "Mucoepidermoid carcinoma" not the answer?

Mucoepidermoid carcinoma carries CRTC1-MAML2.

Why is "Warthin tumour" not the answer?

Warthin tumour is a benign oncocytic tumour without this fusion.

What concept does this question test?

It tests Head and neck tumours: adenoid cystic carcinoma genetics in ENT. Mucoepidermoid carcinoma carries the CRTC1-MAML2 fusion. Acinic cell carcinoma and Warthin tumour have different features.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Head and neck tumours: adenoid cystic carcinoma genetics?

Learn tuning fork results and audiogram patterns by sketching them. Then use the flashcards and the other ENT questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.