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General Medicine · Neurology: restless legs syndrome associations
Sample itemA 32-year-old woman in her third trimester has an irresistible urge to move her legs in the evening, relieved by walking. Which laboratory abnormality should be looked for and corrected?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
C. Low serum ferritin
Restless legs syndrome is linked to brain iron deficiency, and low ferritin is common in pregnancy and anaemia. Correcting iron deficiency can help, and dopamine agonists or gabapentinoids are used for persistent symptoms.
Option by option
A. Raised serum potassium level
Hyperkalaemia does not cause this syndrome.
B. Raised serum calcium level
Hypercalcaemia is not a recognised cause.
C. Low serum ferritin (correct)
Correct. Iron deficiency is a treatable cause and should be checked.
D. Low serum sodium level
Hyponatraemia is not linked to restless legs.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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