Neurophysiology and special senses: subthalamic nucleus: practice question

A Physiology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Physiology · Neurophysiology and special senses: subthalamic nucleus

Sample item

A 70-year-old man has sudden violent flinging movements of the right arm and leg after a small lacunar infarct. Which structure is most likely involved?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Left subthalamic nucleus

Hemiballismus follows a lesion of the subthalamic nucleus, which normally excites the output of the basal ganglia to restrain movement. The basal ganglia act on the opposite side of the body, so right-sided movements indicate a left lesion.

Option by option

  • A. Left substantia nigra pars compacta

    Loss of the substantia nigra pars compacta causes a hypokinetic parkinsonian state.

  • B. Left subthalamic nucleus (correct)

    Correct. A left subthalamic lesion causes contralateral right-sided hemiballismus.

  • C. Left caudate nucleus

    Caudate damage is associated with chorea, not violent flinging movements.

  • D. Right subthalamic nucleus

    A right subthalamic lesion would cause movements on the left.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Physiology question

What is the answer to this Physiology question?

The best answer is B, Left subthalamic nucleus. Hemiballismus follows a lesion of the subthalamic nucleus, which normally excites the output of the basal ganglia to restrain movement.

Why is "Left substantia nigra pars compacta" not the answer?

Loss of the substantia nigra pars compacta causes a hypokinetic parkinsonian state.

Why is "Left caudate nucleus" not the answer?

Caudate damage is associated with chorea, not violent flinging movements.

Why is "Right subthalamic nucleus" not the answer?

A right subthalamic lesion would cause movements on the left.

What concept does this question test?

It tests Neurophysiology and special senses: subthalamic nucleus in Physiology. The basal ganglia act on the opposite side of the body, so right-sided movements indicate a left lesion.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Neurophysiology and special senses: subthalamic nucleus?

For each system, sketch the key graph (pressure–volume loop, oxygen dissociation curve, nephron handling) and explain it aloud. Then use the flashcards and the other Physiology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.