Complications: malignant hyperthermia association: practice question

A Anaesthesia question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Anaesthesia · Complications: malignant hyperthermia association

Sample item

Susceptibility to malignant hyperthermia is associated with which congenital myopathy?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Central core disease

Central core disease is linked to RYR1 mutations and has a strong association with MH. The gold standard diagnostic test is the in vitro caffeine-halothane contracture test on a muscle biopsy.

Option by option

  • A. Guillain-Barre syndrome

    Guillain-Barre is an acquired neuropathy.

  • B. Myasthenia gravis

    Myasthenia gravis is an acquired autoimmune disease.

  • C. Central core disease (correct)

    Correct. Central core disease shares the RYR1 gene.

  • D. Duchenne muscular dystrophy only

    Duchenne dystrophy is linked to rhabdomyolysis and hyperkalaemia with volatile agents or suxamethonium, though not classically MH.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Anaesthesia question

What is the answer to this Anaesthesia question?

The best answer is C, Central core disease. Central core disease is linked to RYR1 mutations and has a strong association with MH.

Why is "Guillain-Barre syndrome" not the answer?

Guillain-Barre is an acquired neuropathy.

Why is "Myasthenia gravis" not the answer?

Myasthenia gravis is an acquired autoimmune disease.

Why is "Duchenne muscular dystrophy only" not the answer?

Duchenne dystrophy is linked to rhabdomyolysis and hyperkalaemia with volatile agents or suxamethonium, though not classically MH.

What concept does this question test?

It tests Complications: malignant hyperthermia association in Anaesthesia. The gold standard diagnostic test is the in vitro caffeine-halothane contracture test on a muscle biopsy.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Complications: malignant hyperthermia association?

Make a table of each agent, its key advantage and its main side effect. Then use the flashcards and the other Anaesthesia questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.