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ENT · Inner ear: Cogan syndrome
Sample itemA 28-year-old has red painful eyes with interstitial keratitis, followed by sudden bilateral hearing loss, vertigo and tinnitus. Syphilis serology is negative. What is the best treatment?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
B. High-dose systemic corticosteroids
Cogan syndrome is an autoimmune vasculitic disorder combining non-syphilitic interstitial keratitis with audiovestibular dysfunction. Early high-dose steroids, and immunosuppressants if needed, may preserve hearing. Cochlear implantation is reserved for profound residual loss.
Option by option
A. Cochlear implantation as first step
Implantation is for established profound loss, not the first step.
B. High-dose systemic corticosteroids (correct)
Correct. Early systemic steroids treat the autoimmune process.
C. Penicillin for 14 days
Penicillin is for syphilis, which is excluded here.
D. Antiviral therapy alone
Antivirals alone will not treat an autoimmune disease.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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