Bone tumours: Ewing sarcoma: practice question

A Orthopaedics question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Orthopaedics · Bone tumours: Ewing sarcoma

Sample item

A 12-year-old has fever, pain and swelling of the femoral diaphysis with onion-peel periosteal reaction. Biopsy shows small round blue cells. Which translocation is characteristic?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. t(11;22) EWSR1-FLI1

Ewing sarcoma carries t(11;22)(q24;q12), fusing EWSR1 and FLI1, and stains for CD99. It typically involves diaphyses of long bones or the pelvis in children, and is sensitive to chemotherapy and radiotherapy.

Option by option

  • A. t(2;13) PAX3-FOXO1

    t(2;13) is characteristic of alveolar rhabdomyosarcoma.

  • B. t(X;18) SS18-SSX

    t(X;18) is characteristic of synovial sarcoma.

  • C. t(11;22) EWSR1-FLI1 (correct)

    Correct. t(11;22) is characteristic of Ewing sarcoma.

  • D. t(9;22) BCR-ABL

    t(9;22) is characteristic of chronic myeloid leukaemia.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Orthopaedics questions

Questions about this Orthopaedics question

What is the answer to this Orthopaedics question?

The best answer is C, t(11;22) EWSR1-FLI1. Ewing sarcoma carries t(11;22)(q24;q12), fusing EWSR1 and FLI1, and stains for CD99.

Why is "t(2;13) PAX3-FOXO1" not the answer?

t(2;13) is characteristic of alveolar rhabdomyosarcoma.

Why is "t(X;18) SS18-SSX" not the answer?

t(X;18) is characteristic of synovial sarcoma.

Why is "t(9;22) BCR-ABL" not the answer?

t(9;22) is characteristic of chronic myeloid leukaemia.

What concept does this question test?

It tests Bone tumours: Ewing sarcoma in Orthopaedics. It typically involves diaphyses of long bones or the pelvis in children, and is sensitive to chemotherapy and radiotherapy.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Bone tumours: Ewing sarcoma?

Pair each fracture with its classic complication and nerve injured. Then use the flashcards and the other Orthopaedics questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.