Bone tumours: synovial sarcoma: practice question

A Orthopaedics question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Orthopaedics · Bone tumours: synovial sarcoma

Sample item

A 25-year-old has a slow-growing soft tissue mass near the knee, with stippled calcification on radiograph. Histology shows a biphasic pattern. Which translocation is typical?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. t(X;18) SS18-SSX

Synovial sarcoma arises in the soft tissue near joints, not from synovium, and has a biphasic spindle and epithelial pattern. It carries t(X;18) producing the SS18-SSX fusion. It may metastasise to lung and to lymph nodes.

Option by option

  • A. t(12;16) FUS-DDIT3

    FUS-DDIT3 characterises myxoid liposarcoma.

  • B. t(11;22) EWSR1-FLI1

    EWSR1-FLI1 is the Ewing sarcoma fusion.

  • C. t(X;18) SS18-SSX (correct)

    Correct. SS18-SSX from t(X;18) characterises synovial sarcoma.

  • D. t(1;13) PAX7-FOXO1

    PAX7-FOXO1 characterises alveolar rhabdomyosarcoma.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Orthopaedics questions

Questions about this Orthopaedics question

What is the answer to this Orthopaedics question?

The best answer is C, t(X;18) SS18-SSX. Synovial sarcoma arises in the soft tissue near joints, not from synovium, and has a biphasic spindle and epithelial pattern.

Why is "t(12;16) FUS-DDIT3" not the answer?

FUS-DDIT3 characterises myxoid liposarcoma.

Why is "t(11;22) EWSR1-FLI1" not the answer?

EWSR1-FLI1 is the Ewing sarcoma fusion.

Why is "t(1;13) PAX7-FOXO1" not the answer?

PAX7-FOXO1 characterises alveolar rhabdomyosarcoma.

What concept does this question test?

It tests Bone tumours: synovial sarcoma in Orthopaedics. It carries t(X;18) producing the SS18-SSX fusion. It may metastasise to lung and to lymph nodes.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Bone tumours: synovial sarcoma?

Pair each fracture with its classic complication and nerve injured. Then use the flashcards and the other Orthopaedics questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.