Ocular oncology: practice question

A Ophthalmology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Ophthalmology · Ocular oncology

Sample item

A 2-year-old child has a white pupillary reflex (leukocoria). The gene commonly involved in the likely diagnosis is located on:

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Chromosome 13q14

Retinoblastoma is the most common intraocular malignancy of childhood and is due to loss of the RB1 tumour suppressor gene on 13q14. Heritable cases carry a risk of second cancers such as osteosarcoma.

Option by option

  • A. Chromosome 13q14 (correct)

    Correct.

  • B. Chromosome 22q12

    22q12 is NF2.

  • C. Chromosome 11p13

    11p13 is WT1, the Wilms tumour gene.

  • D. Chromosome 17p13

    17p13 is TP53.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Ophthalmology question

What is the answer to this Ophthalmology question?

The best answer is A, Chromosome 13q14. Retinoblastoma is the most common intraocular malignancy of childhood and is due to loss of the RB1 tumour suppressor gene on 13q14.

Why is "Chromosome 22q12" not the answer?

22q12 is NF2.

Why is "Chromosome 11p13" not the answer?

11p13 is WT1, the Wilms tumour gene.

Why is "Chromosome 17p13" not the answer?

17p13 is TP53.

What concept does this question test?

It tests Ocular oncology in Ophthalmology. Heritable cases carry a risk of second cancers such as osteosarcoma.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Ocular oncology?

Group the red eye by what to examine and what the pupil does. Then use the flashcards and the other Ophthalmology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.