Try it
Physiology · Acid-base balance
Sample itemA 4-week-old infant with persistent vomiting from pyloric stenosis has arterial blood gas results pH 7.52, PaCO2 48 mmHg and HCO3 38 mmol/L. Which interpretation is correct?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
A. Metabolic alkalosis with partial respiratory compensation
A high pH with a high bicarbonate indicates metabolic alkalosis, here from loss of gastric hydrochloric acid. The raised PaCO2 reflects hypoventilation as the respiratory compensation, which cannot fully correct the pH.
Option by option
A. Metabolic alkalosis with partial respiratory compensation (correct)
Correct. High pH with high bicarbonate is primary metabolic alkalosis, and the raised PaCO2 is the compensation.
B. Respiratory alkalosis with renal compensation
Respiratory alkalosis would show a low PaCO2, not a high one.
C. Metabolic acidosis with respiratory compensation
Metabolic acidosis would give a low pH and low bicarbonate, the opposite of these values.
D. Respiratory acidosis with metabolic compensation
Respiratory acidosis would give a low pH; here pH is high and bicarbonate is the primary change.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
More Physiology questions
- Cardiac cycleDuring which phase of the cardiac cycle are all valves closed while ventricular pressure…
- Renal physiologyWhich substance is freely filtered and neither reabsorbed nor secreted, so that its clea…
- RespirationWhich of the following shifts the oxygen–haemoglobin dissociation curve to the right?
- Renal physiologyWhich of the following favours glomerular filtration?