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Anaesthesia · Critical care, resuscitation, and emergency principles: curriculum recognition
Sample itemAfter three weeks of sepsis and mechanical ventilation, a patient fails weaning because of symmetric flaccid limb weakness with reduced reflexes and spared facial muscles. Nerve conduction shows reduced motor and sensory amplitudes, and the CSF protein is normal. What is the likely diagnosis?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
C. Critical illness polyneuropathy
Critical illness polyneuropathy is an axonal sensorimotor neuropathy that complicates sepsis and multi-organ failure and prolongs ventilation. Myopathy preserves sensory responses, and Guillain-Barre syndrome shows demyelination with raised CSF protein.
Option by option
A. Guillain-Barre syndrome
Guillain-Barre syndrome shows a demyelinating pattern and a raised CSF protein.
B. Critical illness myopathy
Myopathy has normal sensory nerve responses.
C. Critical illness polyneuropathy (correct)
Correct. Axonal reduction of both motor and sensory amplitudes fits this condition.
D. Myasthenic crisis
Myasthenic crisis is fatigable and has a normal nerve conduction amplitude.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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