The mnemonic
9-22 CML, 15-17 APL, 8-14 Burkitt, 14-18 Follicular, 11-14 Mantle
What each word stands for
- 9;22BCR-ABL1 in chronic myeloid leukaemia
- 15;17PML-RARA in acute promyelocytic leukaemia
- 8;14MYC in Burkitt lymphoma
- 14;18BCL2 in follicular lymphoma
- 11;14Cyclin D1 in mantle cell lymphoma
Why it matters clinically
Each fusion has a diagnostic and therapeutic role, such as imatinib and retinoic acid.
Where it stops being reliable
Pairs numbers with disease only; many other translocations are not included.
Teaching aid, still awaiting independent review. Confirm facts in a standard source.