The mnemonic
HIPP
What each word stands for
- HHydralazine
- IIsoniazid
- PProcainamide
- PPhenytoin
Why it matters clinically
Anti-histone antibodies are typical, and the syndrome resolves after stopping the drug.
Where it stops being reliable
Quinidine and others also cause it; hydralazine and procainamide carry the highest risk.
Teaching aid, still awaiting independent review. Confirm facts in a standard source.