Antitubercular drugs: TB preventive therapy: practice question

A Pharmacology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pharmacology · Antitubercular drugs: TB preventive therapy

Sample item

A household contact of a pulmonary TB patient is advised a short-course rifamycin-based preventive regimen given once a week for twelve weeks. Which regimen is this?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. 3HP, rifapentine with isoniazid weekly

3HP combines weekly rifapentine and isoniazid for three months, and the alternatives are 6H, daily isoniazid for six months, and 3HR, three months of daily isoniazid with rifampicin. Shorter regimens improve completion.

Option by option

  • A. 3HP, rifapentine with isoniazid weekly (correct)

    Correct. 3HP is the weekly rifapentine and isoniazid regimen.

  • B. Rifampicin alone for one week

    No such short regimen exists.

  • C. 3HR, daily isoniazid with rifampicin

    3HR is daily, not weekly.

  • D. 6H, daily isoniazid for six months

    6H is daily isoniazid for six months.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Pharmacology question

What is the answer to this Pharmacology question?

The best answer is A, 3HP, rifapentine with isoniazid weekly. 3HP combines weekly rifapentine and isoniazid for three months, and the alternatives are 6H, daily isoniazid for six months, and 3HR, three months of daily isoniazid with rifampicin.

Why is "Rifampicin alone for one week" not the answer?

No such short regimen exists.

Why is "3HR, daily isoniazid with rifampicin" not the answer?

3HR is daily, not weekly.

Why is "6H, daily isoniazid for six months" not the answer?

6H is daily isoniazid for six months.

What concept does this question test?

It tests Antitubercular drugs: TB preventive therapy in Pharmacology. Shorter regimens improve completion.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Antitubercular drugs: TB preventive therapy?

Learn drugs as classes, then the exception in each class that an examiner would pick. Then use the flashcards and the other Pharmacology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.