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Psychiatry · Mood disorders: post-stroke depression
Sample itemDepression after stroke is classically associated with the lesion being located in the
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
C. Left frontal lobe or left basal ganglia
Post-stroke depression is most frequent with left anterior lesions, particularly left frontal cortex and left basal ganglia, and risk is greater the closer the lesion is to the frontal pole. It is common, affecting up to a third of survivors, and worsens recovery. SSRIs are used as treatment.
Option by option
A. Right occipital lobe
Occipital lesions are not specifically linked to depression.
B. Cerebellar vermis
Cerebellar lesions cause ataxia and cognitive affective syndrome, not classically post-stroke depression.
C. Left frontal lobe or left basal ganglia (correct)
Correct. Left frontal and left basal ganglia strokes carry the highest depression risk.
D. Right parietal lobe
Right parietal lesions lead to neglect and anosognosia.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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