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Pathology · Cell adaptation
Sample itemWhat does epithelial dysplasia signify in a biopsy specimen?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
C. Disordered growth with atypical cellular architecture
Dysplasia describes disordered epithelial maturation and cytologic atypia, often arising in chronically injured tissues; it can be premalignant but does not necessarily mean invasive cancer is already present.
Option by option
A. Complete absence of cell division
Dysplastic tissue may still have active cell division.
B. Normal mature tissue organization
Normal organization would not be labeled dysplasia.
C. Disordered growth with atypical cellular architecture (correct)
Correct: dysplasia is abnormal, disordered epithelial growth.
D. A benign increase in cell size only
A simple increase in cell size is hypertrophy, not dysplasia.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.