Gastrointestinal physiology: pancreatic secretion: practice question

A Physiology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Physiology · Gastrointestinal physiology: pancreatic secretion

Sample item

Acidic chyme entering the duodenum causes S cells to release which hormone that stimulates pancreatic bicarbonate secretion?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Secretin

Secretin is released from duodenal S cells in response to acid and stimulates bicarbonate-rich pancreatic and biliary secretion. This neutralises gastric acid in the duodenum.

Option by option

  • A. Secretin (correct)

    Correct. Secretin is the principal acid-responsive bicarbonate signal.

  • B. Ghrelin

    Ghrelin stimulates appetite and growth-hormone release.

  • C. Motilin

    Motilin coordinates migrating motor complexes during fasting.

  • D. Gastrin

    Gastrin stimulates gastric acid secretion.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Physiology question

What is the answer to this Physiology question?

The best answer is A, Secretin. Secretin is released from duodenal S cells in response to acid and stimulates bicarbonate-rich pancreatic and biliary secretion.

Why is "Ghrelin" not the answer?

Ghrelin stimulates appetite and growth-hormone release.

Why is "Motilin" not the answer?

Motilin coordinates migrating motor complexes during fasting.

Why is "Gastrin" not the answer?

Gastrin stimulates gastric acid secretion.

What concept does this question test?

It tests Gastrointestinal physiology: pancreatic secretion in Physiology. This neutralises gastric acid in the duodenum.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Gastrointestinal physiology: pancreatic secretion?

For each system, sketch the key graph (pressure–volume loop, oxygen dissociation curve, nephron handling) and explain it aloud. Then use the flashcards and the other Physiology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.