Immunopathology: practice question

A Pathology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pathology · Immunopathology

Sample item

What is the mechanism of type II hypersensitivity?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Antibodies directed against cells or matrix

Type II reactions involve IgG or IgM binding cell-surface or extracellular-matrix targets, causing complement activation, opsonization, or receptor dysfunction.

Option by option

  • A. IgE-mediated mast-cell degranulation

    IgE mast-cell responses are type I.

  • B. Immune-complex deposition only

    Immune complexes define type III.

  • C. T-cell delayed response

    T-cell reactions are type IV.

  • D. Antibodies directed against cells or matrix (correct)

    Correct: antibody binding to target cells defines type II.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Pathology questions

Questions about this Pathology question

What is the answer to this Pathology question?

The best answer is D, Antibodies directed against cells or matrix. Type II reactions involve IgG or IgM binding cell-surface or extracellular-matrix targets, causing complement activation, opsonization, or receptor dysfunction.

Why is "IgE-mediated mast-cell degranulation" not the answer?

IgE mast-cell responses are type I.

Why is "Immune-complex deposition only" not the answer?

Immune complexes define type III.

Why is "T-cell delayed response" not the answer?

T-cell reactions are type IV.

What concept does this question test?

It tests Immunopathology in Pathology. The correct option holds because: Correct: antibody binding to target cells defines type II.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Immunopathology?

Learn each disease as a bundle: cause, key histology, markers, and the clinical hallmark. Then use the flashcards and the other Pathology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.