Biotransformation: acetylation: practice question

A Biochemistry question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Biochemistry · Biotransformation: acetylation

Sample item

Which drug toxicity is more likely in a slow acetylator taking isoniazid?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Peripheral neuropathy

Slow acetylators metabolize isoniazid more slowly and can have increased adverse effects, including neuropathy and hepatotoxicity. Pyridoxine supplementation helps prevent isoniazid-related neuropathy.

Option by option

  • A. Tendon rupture

    Tendon rupture is associated with fluoroquinolones.

  • B. Peripheral neuropathy (correct)

    Correct. Isoniazid toxicity is enhanced by slow acetylation.

  • C. Ototoxicity from aminoglycosides

    Aminoglycosides cause ototoxicity through a different mechanism.

  • D. Gray baby syndrome

    Gray baby syndrome is associated with chloramphenicol in neonates.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Biochemistry question

What is the answer to this Biochemistry question?

The best answer is B, Peripheral neuropathy. Slow acetylators metabolize isoniazid more slowly and can have increased adverse effects, including neuropathy and hepatotoxicity.

Why is "Tendon rupture" not the answer?

Tendon rupture is associated with fluoroquinolones.

Why is "Ototoxicity from aminoglycosides" not the answer?

Aminoglycosides cause ototoxicity through a different mechanism.

Why is "Gray baby syndrome" not the answer?

Gray baby syndrome is associated with chloramphenicol in neonates.

What concept does this question test?

It tests Biotransformation: acetylation in Biochemistry. Pyridoxine supplementation helps prevent isoniazid-related neuropathy.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Biotransformation: acetylation?

Build one table of enzyme deficiency, disease, inheritance and key finding, then revise it by spaced recall. Then use the flashcards and the other Biochemistry questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.