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ENT · Nose and paranasal sinuses: mucormycosis hyphae
Sample itemA diabetic with ketoacidosis has facial pain and a black necrotic area on the middle turbinate. Which microscopic appearance is expected on KOH mount or biopsy?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
D. Broad, ribbon-like aseptate hyphae branching at right angles
Rhino-orbito-cerebral mucormycosis is caused by Mucorales, which have broad, thin-walled, mostly aseptate hyphae with right-angle branching and invade vessels causing infarction and black eschar. Aspergillus shows narrow septate hyphae branching at acute angles. Treatment is correction of acidosis, urgent debridement and amphotericin B.
Option by option
A. Budding yeasts with pseudohyphae
Budding yeasts with pseudohyphae are typical of Candida.
B. Narrow septate hyphae branching at 45 degrees
Thin septate hyphae with acute-angle branching describe Aspergillus.
C. Spherules containing endospores
Spherules with endospores are seen in Coccidioides.
D. Broad, ribbon-like aseptate hyphae branching at right angles (correct)
Correct. Broad aseptate right-angle branching hyphae are typical of Mucorales.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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