Gynaecological oncology: Peutz-Jeghers syndrome: practice question

A OBG question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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OBG · Gynaecological oncology: Peutz-Jeghers syndrome

Sample item

Which pair of gynaecological tumours is associated with Peutz-Jeghers syndrome?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Sex cord tumour with annular tubules and adenoma malignum of the cervix

Peutz-Jeghers syndrome (STK11 mutation) is linked to sex cord tumours with annular tubules and to minimal deviation adenocarcinoma (adenoma malignum) of the cervix, in addition to gut hamartomas and mucocutaneous pigmentation.

Option by option

  • A. Sex cord tumour with annular tubules and adenoma malignum of the cervix (correct)

    Correct. These two tumours are the classic gynaecological associations.

  • B. Brenner tumour and serous cystadenoma

    Brenner and serous tumours are sporadic epithelial neoplasms.

  • C. Yolk sac tumour and choriocarcinoma

    Yolk sac tumour and choriocarcinoma are germ cell and trophoblastic tumours.

  • D. Dysgerminoma and clear cell carcinoma

    Dysgerminoma is linked to gonadal dysgenesis and not to this syndrome.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More OBG questions

Questions about this OBG question

What is the answer to this OBG question?

The best answer is A, Sex cord tumour with annular tubules and adenoma malignum of the cervix. Peutz-Jeghers syndrome (STK11 mutation) is linked to sex cord tumours with annular tubules and to minimal deviation adenocarcinoma (adenoma malignum) of the cervix, in addition to gut hamartomas and mucocutaneous pigmentation.

Why is "Brenner tumour and serous cystadenoma" not the answer?

Brenner and serous tumours are sporadic epithelial neoplasms.

Why is "Yolk sac tumour and choriocarcinoma" not the answer?

Yolk sac tumour and choriocarcinoma are germ cell and trophoblastic tumours.

Why is "Dysgerminoma and clear cell carcinoma" not the answer?

Dysgerminoma is linked to gonadal dysgenesis and not to this syndrome.

What concept does this question test?

It tests Gynaecological oncology: Peutz-Jeghers syndrome in OBG. The correct option holds because: Correct. These two tumours are the classic gynaecological associations.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Gynaecological oncology: Peutz-Jeghers syndrome?

Learn management algorithms as steps: PPH, eclampsia, ectopic pregnancy. Then use the flashcards and the other OBG questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.