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Ophthalmology · Cataract: phacolytic glaucoma
Sample itemA patient with a hypermature cataract develops a painful red eye with high IOP, an open angle and white flakes in the anterior chamber. What is the mechanism?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
B. Trabecular blockage by macrophages laden with lens protein
Lens proteins leak through the intact capsule and are phagocytosed by macrophages, which clog the trabecular meshwork. Treatment is IOP control followed by cataract extraction.
Option by option
A. Neovascularisation of the angle
Neovascular glaucoma follows ischaemic retinal disease.
B. Trabecular blockage by macrophages laden with lens protein (correct)
Correct. Macrophages with lens protein block outflow.
C. Steroid response
No steroids are involved.
D. Pupillary block by the swollen lens
Pupillary block describes phacomorphic glaucoma with a closed angle.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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