Oncology: Ewing sarcoma: practice question

A Pediatrics question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pediatrics · Oncology: Ewing sarcoma

Sample item

An adolescent has pain and swelling of the femoral diaphysis with fever. X-ray shows an onion-peel periosteal reaction. Which translocation is typical?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. t(11;22) EWS-FLI1

Ewing sarcoma is a small round blue cell tumour of the diaphysis, mimicking osteomyelitis, with the t(11;22) translocation. Osteosarcoma affects the metaphysis and shows Codman triangle and sunburst pattern. Management is chemotherapy with surgery or radiotherapy.

Option by option

  • A. t(9;22)

    t(9;22) is the Philadelphia chromosome.

  • B. t(11;22) EWS-FLI1 (correct)

    Correct. t(11;22) is typical.

  • C. t(2;13)

    t(2;13) is found in alveolar rhabdomyosarcoma.

  • D. t(8;14)

    t(8;14) is Burkitt lymphoma.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Pediatrics question

What is the answer to this Pediatrics question?

The best answer is B, t(11;22) EWS-FLI1. Ewing sarcoma is a small round blue cell tumour of the diaphysis, mimicking osteomyelitis, with the t(11;22) translocation.

Why is "t(9;22)" not the answer?

t(9;22) is the Philadelphia chromosome.

Why is "t(2;13)" not the answer?

t(2;13) is found in alveolar rhabdomyosarcoma.

Why is "t(8;14)" not the answer?

t(8;14) is Burkitt lymphoma.

What concept does this question test?

It tests Oncology: Ewing sarcoma in Pediatrics. Osteosarcoma affects the metaphysis and shows Codman triangle and sunburst pattern. Management is chemotherapy with surgery or radiotherapy.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Oncology: Ewing sarcoma?

Memorise milestones and the vaccine schedule as tables and revise them often. Then use the flashcards and the other Pediatrics questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.