The mnemonic
Lead, Length, Overdiagnosis
What each word stands for
- LeadLead time bias: earlier detection appears as longer survival
- LengthLength time bias: slow-growing disease is more likely to be detected
- OverdiagnosisDetection of disease that would never have caused harm
Why it matters clinically
Explains why survival gains from screening must be judged by mortality.
Where it stops being reliable
Not a full list of biases; selection and volunteer bias also affect screening studies.
Teaching aid, still awaiting independent review. Confirm facts in a standard source.