Vesiculobullous disorders: drug-induced pemphigus: practice question

A Dermatology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Dermatology · Vesiculobullous disorders: drug-induced pemphigus

Sample item

Which drug is the classic cause of drug-induced pemphigus, typically pemphigus foliaceus-like, via its thiol group?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Penicillamine

Thiol-containing drugs, notably penicillamine and captopril, are the commonest triggers of drug-induced pemphigus. Lesions often resemble pemphigus foliaceus and may resolve when the drug is stopped. Non-thiol triggers include rifampicin and some cephalosporins.

Option by option

  • A. Amlodipine

    Amlodipine is not a classic cause.

  • B. Metformin

    Metformin is not associated.

  • C. Atenolol

    Atenolol is not a classic cause.

  • D. Penicillamine (correct)

    Correct. Penicillamine is the classic thiol drug trigger.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Dermatology question

What is the answer to this Dermatology question?

The best answer is D, Penicillamine. Thiol-containing drugs, notably penicillamine and captopril, are the commonest triggers of drug-induced pemphigus.

Why is "Amlodipine" not the answer?

Amlodipine is not a classic cause.

Why is "Metformin" not the answer?

Metformin is not associated.

Why is "Atenolol" not the answer?

Atenolol is not a classic cause.

What concept does this question test?

It tests Vesiculobullous disorders: drug-induced pemphigus in Dermatology. Lesions often resemble pemphigus foliaceus and may resolve when the drug is stopped. Non-thiol triggers include rifampicin and some cephalosporins.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Vesiculobullous disorders: drug-induced pemphigus?

Learn each condition by its primary lesion, site and signature sign. Then use the flashcards and the other Dermatology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.