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Dermatology · Pigmentary disorders
Sample itemA man has well-demarcated chalk-white macules on his hands and around his mouth. A skin biopsy shows an absence of melanocytes. What is the diagnosis?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
D. Vitiligo
Vitiligo is an acquired autoimmune loss of melanocytes, often with Koebner phenomenon and associations with thyroid disease and other autoimmune conditions.
Option by option
A. Nevus anaemicus
Nevus anaemicus is a congenital pale patch that does not show absent melanocytes.
B. Tinea versicolor
Tinea versicolor has scale and fungal elements.
C. Pityriasis alba
Pityriasis alba has hypopigmented, scaly patches with melanocytes present.
D. Vitiligo (correct)
Correct.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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