Haematopathology: practice question

A Pathology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pathology · Haematopathology

Sample item

Which peripheral-blood finding should raise concern for acute leukaemia and prompt urgent haematology evaluation?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Circulating blasts with cytopenias

Acute leukaemia often releases immature blast cells into blood and suppresses normal marrow production, producing anaemia, thrombocytopenia, infection risk, or bleeding that require urgent specialist assessment.

Option by option

  • A. Normal mature red-cell morphology

    Normal red-cell morphology does not suggest acute leukaemia.

  • B. Circulating blasts with cytopenias (correct)

    Correct: blasts plus cytopenias are a concerning acute-leukaemia pattern.

  • C. Mild isolated eosinophilia after allergy

    Mild allergy-related eosinophilia is not the same as circulating blasts.

  • D. High HDL cholesterol

    HDL cholesterol does not diagnose marrow malignancy.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Pathology question

What is the answer to this Pathology question?

The best answer is B, Circulating blasts with cytopenias. Acute leukaemia often releases immature blast cells into blood and suppresses normal marrow production, producing anaemia, thrombocytopenia, infection risk, or bleeding that require urgent specialist assessment.

Why is "Normal mature red-cell morphology" not the answer?

Normal red-cell morphology does not suggest acute leukaemia.

Why is "Mild isolated eosinophilia after allergy" not the answer?

Mild allergy-related eosinophilia is not the same as circulating blasts.

Why is "High HDL cholesterol" not the answer?

HDL cholesterol does not diagnose marrow malignancy.

What concept does this question test?

It tests Haematopathology in Pathology. The correct option holds because: Correct: blasts plus cytopenias are a concerning acute-leukaemia pattern.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Haematopathology?

Learn each disease as a bundle: cause, key histology, markers, and the clinical hallmark. Then use the flashcards and the other Pathology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.