Neuropathology: practice question

A Pathology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pathology · Neuropathology

Sample item

Eosinophilic intracytoplasmic inclusions in the pigmented neurons of the substantia nigra are called:

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Lewy bodies

Lewy bodies consist of aggregated alpha-synuclein and are the hallmark of Parkinson disease and Lewy body dementia. Loss of dopaminergic neurons in the pars compacta causes the motor syndrome.

Option by option

  • A. Lewy bodies (correct)

    Correct.

  • B. Neurofibrillary tangles

    Neurofibrillary tangles of tau are seen in Alzheimer disease.

  • C. Pick bodies

    Pick bodies are tau-positive inclusions in frontotemporal dementia.

  • D. Negri bodies

    Negri bodies are inclusions of rabies in neurons.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Pathology questions

Questions about this Pathology question

What is the answer to this Pathology question?

The best answer is A, Lewy bodies. Lewy bodies consist of aggregated alpha-synuclein and are the hallmark of Parkinson disease and Lewy body dementia.

Why is "Neurofibrillary tangles" not the answer?

Neurofibrillary tangles of tau are seen in Alzheimer disease.

Why is "Pick bodies" not the answer?

Pick bodies are tau-positive inclusions in frontotemporal dementia.

Why is "Negri bodies" not the answer?

Negri bodies are inclusions of rabies in neurons.

What concept does this question test?

It tests Neuropathology in Pathology. Loss of dopaminergic neurons in the pars compacta causes the motor syndrome.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Neuropathology?

Learn each disease as a bundle: cause, key histology, markers, and the clinical hallmark. Then use the flashcards and the other Pathology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.