Granulomatous disease: practice question

A Pathology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pathology · Granulomatous disease

Sample item

Non-caseating granulomas with Schaumann bodies and asteroid bodies are typical of:

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Sarcoidosis

Sarcoidosis shows compact, non-necrotising epithelioid granulomas, often with bilateral hilar lymphadenopathy. Tuberculosis characteristically has caseation.

Option by option

  • A. Histoplasmosis

    Histoplasmosis granulomas contain small intracellular yeasts and may caseate.

  • B. Lepromatous leprosy

    Lepromatous leprosy shows foamy macrophages (Virchow cells), not well-formed granulomas.

  • C. Sarcoidosis (correct)

    Correct. Remember it is a diagnosis of exclusion once infection is ruled out.

  • D. Tuberculosis

    Tuberculous granulomas are caseating.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Pathology question

What is the answer to this Pathology question?

The best answer is C, Sarcoidosis. Sarcoidosis shows compact, non-necrotising epithelioid granulomas, often with bilateral hilar lymphadenopathy.

Why is "Histoplasmosis" not the answer?

Histoplasmosis granulomas contain small intracellular yeasts and may caseate.

Why is "Lepromatous leprosy" not the answer?

Lepromatous leprosy shows foamy macrophages (Virchow cells), not well-formed granulomas.

Why is "Tuberculosis" not the answer?

Tuberculous granulomas are caseating.

What concept does this question test?

It tests Granulomatous disease in Pathology. Tuberculosis characteristically has caseation.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Granulomatous disease?

Learn each disease as a bundle: cause, key histology, markers, and the clinical hallmark. Then use the flashcards and the other Pathology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.