Immunopathology: practice question

A Pathology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pathology · Immunopathology

Sample item

Which hypersensitivity type is mediated by IgE and mast-cell activation?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Type I hypersensitivity

Type I hypersensitivity is immediate and involves allergen-specific IgE bound to mast cells, causing mediator release after re-exposure.

Option by option

  • A. Type I hypersensitivity (correct)

    Correct: IgE-mediated mast-cell activation is type I.

  • B. Type III hypersensitivity

    Type III involves immune-complex deposition.

  • C. Type IV hypersensitivity

    Type IV is T-cell mediated and delayed.

  • D. Type II hypersensitivity

    Type II involves antibodies against cell or matrix targets.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Pathology questions

Questions about this Pathology question

What is the answer to this Pathology question?

The best answer is A, Type I hypersensitivity. Type I hypersensitivity is immediate and involves allergen-specific IgE bound to mast cells, causing mediator release after re-exposure.

Why is "Type III hypersensitivity" not the answer?

Type III involves immune-complex deposition.

Why is "Type IV hypersensitivity" not the answer?

Type IV is T-cell mediated and delayed.

Why is "Type II hypersensitivity" not the answer?

Type II involves antibodies against cell or matrix targets.

What concept does this question test?

It tests Immunopathology in Pathology. The correct option holds because: Correct: IgE-mediated mast-cell activation is type I.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Immunopathology?

Learn each disease as a bundle: cause, key histology, markers, and the clinical hallmark. Then use the flashcards and the other Pathology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.