Try it
Dermatology · Bacterial infections: ecthyma gangrenosum
Sample itemA neutropenic leukaemia patient has painless, round, punched-out ulcers with black necrotic centres surrounded by an erythematous halo and signs of sepsis. Which organism is most often responsible?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
A. Pseudomonas aeruginosa
Ecthyma gangrenosum reflects perivascular bacterial invasion, classically by Pseudomonas aeruginosa in neutropenic patients, and indicates bacteraemia. Prompt antipseudomonal therapy is required.
Option by option
A. Pseudomonas aeruginosa (correct)
Correct. Pseudomonas invades vessel walls producing necrotic ulcers.
B. Treponema pallidum
Treponema causes painless chancre or gumma, not necrotic ulcers with sepsis.
C. Group A streptococcus
Group A streptococcus causes simple ecthyma in the skin of healthy people but not this septic form.
D. Mycobacterium tuberculosis
M. tuberculosis causes chronic ulcers like scrofuloderma.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
More Dermatology questions
- Blistering disordersA patient has flaccid blisters that rupture easily and a positive Nikolsky sign. Which c…
- LeprosyIn which type of leprosy is the lepromin test strongly positive?
- Pigmentary disordersA man has well-demarcated chalk-white macules on his hands and around his mouth. A skin…
- Drug reactionsWhich of the following drugs is a well-recognised trigger of Stevens–Johnson syndrome an…