Connective tissue disease: subacute cutaneous lupus: practice question

A Dermatology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Dermatology · Connective tissue disease: subacute cutaneous lupus

Sample item

A photosensitive woman has annular, psoriasiform lesions on the shoulders and upper back, and her newborn later has congenital heart block. Which antibody is most likely present?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Anti-Ro (SSA)

Subacute cutaneous lupus erythematosus is strongly associated with anti-Ro/SSA, which can cross the placenta and cause neonatal lupus with congenital heart block. Drugs such as hydrochlorothiazide may trigger it.

Option by option

  • A. Anti-Jo-1

    Anti-Jo-1 is linked to antisynthetase syndrome.

  • B. Anti-centromere

    Anti-centromere is linked to limited systemic sclerosis.

  • C. Anti-Scl-70

    Anti-Scl-70 is linked to diffuse systemic sclerosis.

  • D. Anti-Ro (SSA) (correct)

    Correct. Anti-Ro/SSA is linked to SCLE and neonatal lupus.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Dermatology question

What is the answer to this Dermatology question?

The best answer is D, Anti-Ro (SSA). Subacute cutaneous lupus erythematosus is strongly associated with anti-Ro/SSA, which can cross the placenta and cause neonatal lupus with congenital heart block.

Why is "Anti-Jo-1" not the answer?

Anti-Jo-1 is linked to antisynthetase syndrome.

Why is "Anti-centromere" not the answer?

Anti-centromere is linked to limited systemic sclerosis.

Why is "Anti-Scl-70" not the answer?

Anti-Scl-70 is linked to diffuse systemic sclerosis.

What concept does this question test?

It tests Connective tissue disease: subacute cutaneous lupus in Dermatology. Drugs such as hydrochlorothiazide may trigger it.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Connective tissue disease: subacute cutaneous lupus?

Learn each condition by its primary lesion, site and signature sign. Then use the flashcards and the other Dermatology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.